The O. B. Grant House is described in a 1896 local publication as one of the finest homes in the town. The residence, dating from the last third of the nineteenth century, also reflects remodelings from the late nineteenth or early twentieth century. The period of significance of the Grant House began in 1870 with its construction and ended in 1920 with the death of its original owner.
The house was home to Oscar B. Grant, a regionally significant figure in the nineteenth-century tanning industry and a leading local businessman in Ridgway, Pennsylvania. The property is associated with the nineteenth-century leather tanning industry in northcentral Pennsylvania and with the work of the Ridgway-based Hyde-Murphy Company, a locally, regionally, and nationally known builder and producer of architectural millwork and ornament.